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In Remembrance
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Join Date: Aug 2006
Posts: 3,772
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In Remembrance
Join Date: Aug 2006
Posts: 3,772
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A possible explanation...
...for the facts that although PD does not appear to be hereditary but does become more likely in families lies in the bacterial endotoxin element that I mention from time to time.
1) Exposure to the toxin (LPS) in the womb or early life sets the stage for later PD. That has been shown in a mouse at least.
2) LPS from dead bacteria is the primary component of house dust. So members of a given family would likely have similar exposures.
3) This would lead to the situation that was found. Growing up in the same house or same family with similar housekeeping habits would increase the chance of PD. Twins separated at birth should exhibit a different pattern but only if allowance is made for prenatal conditions.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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