I take as my dr says a baby dose since I started it and maybe don't really need it yet I don't want to go off as my body is used to it I take 2-100 pills at night I have tried to go to 300 I just can't get out of bed with too much fatigue if take that much my dr wants me to go up to 600 and take during the day... no way...I can get used to it I am drug sensitive so those taking as much as they do they are lucky as when I get bad pain with this I don't know what I will do.