Hi, Kim. No, neither of my parents had polio or post-polio syndrome.

Who knows what effects the polio vaccine had on anyone. I won't get into the discussion on vaccines because it takes up too much energy!

Post-polio syndrome gets worse with aging, certain diets (not enough nutrition/too many free radicals), etc.

Is it possible that there is a genetic mutation involved with acetylcholine in the children of anyone who had polio? Absolutely. But good luck pinning down any corresponding research proving that.

I would love to know the mechanisms that create channelopathy issues in children of those who have had polio or PPS. It's logical that there is a connection, given the pathophysiology of polio.

The first article below is very good in explaining why PPS patients benefit from Mestinon and other similar drugs.

How is your mom doing?

Annie

http://www.post-polio.org/edu/hpros/task/pathclue.html

http://books.google.com/books?id=4CF...holine&f=false

There is also anecdotal use of L-Carnitine, CoQ10, etc.