I know in the clinic I go to they are moving people who are JCV + onto 6 or 8 week cycles. I can't give you an answer about whether to stay on it or not but I would keep the port in even while you try switching to a pill. You never know if you will have to or want to go back to Tysabri. Obviously if you can tolerate the pills and don't have relapses you can then pull the port. But don't rush that decision. Good luck Lynn!