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Old 09-13-2014, 09:54 AM
soccertese soccertese is offline
Magnate
 
Join Date: Nov 2007
Posts: 2,531
15 yr Member
soccertese soccertese is offline
Magnate
 
Join Date: Nov 2007
Posts: 2,531
15 yr Member
Default 1994 paper dietary factors in the management of parkinson's using l-dopa

http://apjcn.nhri.org.tw/server/Mark...01994/P182.pdf

not sure if everything presented here is still accurate but if it is has some good ideas of how to try to minimize protein interference, increase l-dopa getting to the brain.

also discusses fava and mucana as options for 3rd world, gives l-dopa content.

here's a good explanation as to why you want to minimize the time l-dopa stays in your stomach:
l-dopa is otimally absorbed from the duodenum and proximal jejunum. the drug is not absorbed across the gastric mucosa, but oral doses are dependent upon gastric emptying for access to absorption sites. the rate of gastric emptying is chiefly determined by the energy content of food and is inversely proportional to the energy density of the meal. thus fat will retard gastric emptying to a greater degree than carbohydrates or protein. low gastric acidity slows emptying although routine administration of antacids to pd patients doesn't improve l-dopa absorption. some types of dietary fiber increase food viscosity and slow gastric emptying. THE GASTRIC MUCOSA CONTAINS THE ENZYME DOPA DECARBOXYLASE, WHICH WILL CATALYZE UNWANTED CONVERSION OF L-DOPA TO DOPAMINE, REDUCING THE AMOUNT OF L-DOPA AVAILABLE FOR SUBSEQUENT ABSORPTION FROM DOSES AFFECTED BY DELAYED GASTRIC EMPTYING.

remember, dopamine doesn't cross the BBB which is why we take l-dopa.
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GerryW (09-13-2014), lab rat (09-14-2014), shcg (09-13-2014), wxxu (09-13-2014)