It is interesting the UK clinical trial provides a delivery system with multiple infusions of the GDNF Protein, and the US method delivers the GDNF gene in a one time surgery.

I hope they are both successful , but it will be interesting to see which one is more effective. I can see pros and cons as a pwp -- for the uk delivery system you live with ports in your head and once established, i believe they plan for a once a month infusion of the GDNF a protein. The US method involves a one time brain surgery delivering GDNF genes via AAV. What if the Gdnf genes stop multiplying at some point?

Of course I am assuming both will work. We will know with time.

Jean
Human participant #3 in the NIH GDNF GENE therapy trial, surgery date March7, 2014