Thanks for your reply, Icehouse! I have been feeling some pain in my feet lately, which I hadn't really before. I had heard that sometimes when nerves are getting "regenerated", that you may feel some pain, since they are "coming back". I have no idea if that's true or not, but I am hoping so, and that my pain is because of that and not that I am getting progressively worse . Still faithfully taking Benfotiamine, B-12 Methyl and R-ALA.