Hi,

I just found this thread, and unfortunately most of the information relevant to my situation is 6+ years old. Hopefully mrsD is still around with all of the excellent information...

A few months ago I noticed petechiae on my thighs. Then my period came early. Then I became exhausted. Then sick and dizzy. Finally just recently, after seeing a dozen doctors and specialists, they've decided that I probably have Hashimoto's, although I don't have the antibodies.

Anyways, a month into this (in June) I woke up in the middle of the night with my left arm numb and tingly and my heart POUNDING. I was terrified and thought I was having a stroke or heart attack. I called the paramedics, went to the ER, and they said nothing was wrong with me. I went home, and it began getting much worse. The numbness in my left arm spread to my right, then into my legs, then feet, then knees, then hips, then my face and the inside of my mouth. I was sure I was developing MS. My GP had no idea what was happening. A week later I call for the results of some labwork I'd had done. I have requested a B6 test, along with B12 and a thyroid panel, and a few other things. I requested B6 because I had read somewhere that it was important for thyroid function.
My B6 was at 76 with the range being 2-29. I began researching, only to find that the numbness was neuropathy, and that it was probably related to the B6. I went in to see a neurologist. I was tested for MS and ALS, negative. Also negative for any LARGE fiber neuropathy, which is useless, as I believe B6 causes small fiber neuropathy.
My only source of B6 was 25mg in a multivitamin I'd been taking for years. I stopped taking it and went on a strict low B6 diet. All numbness faded within 2 weeks. I checked my B6 level again and it was in the low 20s.

That was several months ago and I'm still having some issues getting my thyroid under control, but I have not had any numbness. Recently, my B6 is back up to 29, a couple of points outside of this labs range. I don't know why it would be coming back up.

So my question is, should I start taking P5P? I've had the Organix test done and there were no abnormalities with my B-Complex Vitamin Markers. My folate, B12, magnesium, and homocysteine are all fine. My only issues are the B6 and my low/normal T3 and erratic TSH. I did the 23andMe test and ran it through Genetic Genie and Promethease. I'm hetero for MTHFR C667T and 03P39P, also MTRR A664A. Homo for CBS A360A and VDR Taq.

Mayo's lab tests P5P levels. My immunologist has agreed to try to have my blood sent to them. We're also testing my B2. I suspect I have a deficiency, but if so, would my level drop and symptoms fade when stopping the multi with 25mg pyrodoxine? Would a deficiency that's showing up as elevated pyrodoxine show low levels of P5P when tested or should I be testing something else?