L-tryptophan does cross the blood brain barrier. If it didn't you wouldn't ever have serotonin made there.

It is serotonin itself that does not cross. The serotonin in the body, cannot enter the brain.

L-tryptophan does cross but does have a problem if other amino acids from protein are in high amounts in the serum..(following a protein meal). These other aminos compete for crossing so tryptophan is reduced, but not totally blocked. It is recommended that L-tryptophan be taken away from protein containing food by several hours...and can be taken with carbohydrates instead. It is thought that the body controls the serotonin synthesis in brain, by this mechanism, to prevent high levels from occurring.

Hydroxyzine is an antihistamine (Atarax) and like its cousin Benadryl is very sedating. Another product similar OTC is Unisom, which is also sedating. These just make you drowsy.

Dramamine II however, (meclizine) does have some tranquilizing properties. Meclizine is Antivert, and also an antihistamine (used for vertigo and nausea,and seasickness), but it has some weak tranquilizing actions like the antipsychotics. Dramamine-II is OTC and typically found in small packages for seasickness--10 or 12 tablets. All of these I've mentioned are chemically derived from early antipsychotics. Phenergan also (which retains some antiemetic actions from its parent Thorazine).