Quote:
Originally Posted by Mark in Idaho
My comment was in response to Gerd and stomach issues. The blood thinning is another issue. I bleed like a stuck pig.
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Aspirin and NSAIDs will cause stomach bleeding systemically, not just locally.
It does this by inhibiting the Cox-1 enzyme in fatty acid chemistry.
Cox-1 is responsible for maintaining the mucus coat of the stomach and its integrity from acid. Removing it, leads to
erosions and damage, and ulcers. This is a systemic effect exerted by aspirin in the blood stream affecting the cells lining the stomach. Just like the proton pump inhibitors reduce acid production systemically the same way (not locally on the stomach lining itself). Proton pump inhibitors, are enteric coated to escape stomach acid which deactivates them.
Aspirin also has effects on clotting and platelets. This can encourage a bleed that has started in the stomach, by thinning the blood.
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Weezie looking at petunias 8.25.2017
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