I have also taken Carnosine, ALA, B-complex etc. for a year or so with similar non-dramatic results. I wonder if reducing sugar would help. Alpha synuclein build up took years to occur (due to excess High Fructose Corn Syrup (HFCS) which is now in most foods and regular sugar) so maybe it will take years to clear up the damage done. Trehalose sugar apparently doesn't cause AGE build up as it doesn't cause the Maillard effect which results in glycation/AGE to occur.