Quote:
Originally Posted by lurkingforacure
Seems like an L-dopa patch would solve this problem: no need for carbidopa since it's not being taken orally.
We have struggled for years with how to take a B vit. supplement without messing up the meds. Even drinking a Vitamin Water (which has B in it) has the effect, for us, of making our drugs even less effective than they already are. If anyone has any suggestions on how to take a B vitamin supplement while you are also having to take sinement/generic version, please share with us all.
B is critical: they have found in nursing homes a staggering majority of patients were deficient in B vitamins. A great many improved when given B (I'm not saying the patients threw away their canes and jumped out of their wheelchairs, but there was improvement, significantly of the cognitive variety). Of course, this is not a hot topic for pharma  |
l-dopa patch isn't possible, l-dopa doesn't pass thru the skin well plus it would have to deliver a lot of l-dopa compared to an agonist like neupro. you still need carbidopa even if you bypass the stomach and small intestine since the blood still circulates thru every cell in the body. the gel used in the duodopa pump contains carbidopa.
http://www.abbvie.ca/content/dam/abb...DOPA_PM_EN.pdf
neuoderm tried a patch, it failed, now developing a insulin pump like device to subcutaneously deliver l-dopa, not sure if their gel has carbidopa or you take it orally.
https://www.michaeljfox.org/foundati...p?grant_id=225
agonists were developed because of this problem with l-dopa breaking down outside and inside the brain , some medical professionals think we need a better agonist and there are already 3 once a day products, mirapex-xr, requip-xr and neupro.