They are related chemically. Nortriptyline is the active metabolite of amitriptyline. "Nor" is just faster acting in the body by a couple of hours.
If you have a liver metabolic enzyme deficiency:
Quote:
Metabolism
Nortriptyline is metabolized in the liver by the hepatic enzyme CYP2D6. Approximately 7-10% of caucasians are poor metabolizers and might experience more adverse effects, so a lower dosage is often necessary in these individuals.[6] Blood levels of nortriptyline should be obtained during long term treatment to avoid toxicity and optimize response.
|
but....
Quote:
However, the incidence of side effects with nortriptyline is lower than with the first-generation tricyclics (e.g., imipramine (Tofranil), amitriptyline (Elavil)). For this reason it is often used in elder patients instead of other TCAs to reduce side effects and improving patient's compliance.
|
from
http://en.wikipedia.org/wiki/Nortriptyline
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
************************************
.
Weezie looking at petunias 8.25.2017
****************************
These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.