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Old 11-05-2014, 07:15 PM
johnt johnt is offline
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Join Date: Apr 2009
Location: Stafford, UK
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15 yr Member
johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
15 yr Member
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I've come across a paper (mainly written in Spanish, which I don't speak - but let's not stop there) which points out that there is no agreed conversion factor between levodopa and other PD drugs.

For each drug and each method of calculating the equivalence Cervantes-Arriagal et al. [1] give the conversion factor. I precis their table as follows:

Drug/Lowest conversion factor/Highest conversion factor/Weighted average
L-dopa/1/1/1
L-dopa CR/0.70/0.77/0.74
Pergolide/100/100/100
Cabergoline/66.6/100/80.12
Bromocriptine/10/10/10
Stalevo/1.2/1.33/1.25
Pramipexol/67/100/89
Ropinirole/16.67/33.3/21.3
Lisuride/100/100/100
Apomorphine/8/10/8.25

(N.B. the l-dopa entry is for l-dopa with carbidopa.)

What sticks out to me is the large range for ropinirole: a factor of two difference between the highest and lowest estimates. Also, so many of the estimates are "round numbers", such as 100, which suggests that the estimates are very rough. That said, I think it is very useful to have an idea of the relative power of drugs.

Reference

[1] "Cálculo de unidades de equivalencia de levodopa en enfermedad de Parkinson"
Amin Cervantes-Arriaga1, Mayela Rodríguez-Violante1, Alejandra Villar-Velarde, Teresa Corona
Arch Neurocien (Mex) Vol. 14, No. 2: 116-119; 2009
http://www.medigraphic.com/pdfs/arcn...09/ane092f.pdf

John
__________________
Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg

Last edited by johnt; 11-05-2014 at 07:23 PM. Reason: Typo
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