I have only just seen your post but just wanted to make the point that I have been diagnosed with SLE/UCTD for many years despite having low or neg ANA and no other auto immune profile other than leucopenia and intermittent low C3C4. My disease has followed a steady and largely benign path for years until 2012 when it suddenly changed pace and course. For the past 2 years the onslaught has been on my nerves thus affecting my limbs, my strength, my breathing plus functioning of my left eye/left side of my face and so on. The problems come in pulses often alongside arthritis, erythema, MASSIVE fatigue and malaise.

My point is, I clearly have auto-immune disease with or without the 'typical' lab test results. I too have 3 young children and was so fit, I couldn't stay still for a moment. That was then, now is a different story.

Hope this helps. Clare