Originally Posted by wendy s

Here is an interim report that I found on MJFF. I couldn't find anything more recent either on MJFF or PubMed.

"Significant technical issues, such as delivery losses due to the “sticky” nature of gene vector, prevented reproducible adequate transfection following intranasal administration. While a sensitive histological/immunohistochemical procedure for visualizing trace GDNFflag in intracellular vesicles was developed, further studies are required to properly test whether intranasal, gene-derived, GDNF can make direct contact with receptors expressed by midbrain dopaminergic neurons."

April 2012