It has been around 72 hrs since my last 10-325 pill. The Dr. gave me Tylenol w/codiene as replacement. The first 24 hrs were the worst with what I feel is a combination of psysical and psycological feelings. The Tylenol were not effective for the pain at first. They are still not as good overall but the pain is managable after you get past the first day. I was able to stop the regimine of Miralax and colase to combat the constipation. The stool was readjusting for about a couple days but has settled to better than it has been for a long time. I am happy to stop buying two things that had been part of a daily routine. Also happy to not be somewhere in between "river gravel' and "dammit". Sorry about so much bathroom commentary but that is just how exciting my life is,haha. Wishing you all health, happiness where you can find it, and continuous improvement. Ken in Texas.