I was a volunteer in the milnaciprin study and had a bad reaction to it. I broke out in huge welts on my thighs a few hours after half an initial dose. It's obvious I was on the drug - not placebo. It was a long hassle to get into the study and once in they tried to keep me in even though I reacted badly. Have also been in lyrica study that made me feel terrible. Started throwing it out. I'm not sure how well the adverse reactions are really recorded. I've been diagnosed w/mild fibro but think it's getting worse and/or I have other disease. I thought the glucosamine chondroitin was some help but gave me terrible stomach ache and diarrhea - of course I'm allergic to iodine. The anti depressants really scare me - have refused that route. No narcs either. Hope to find something!