I was having s/e from Lipitor and Mrs D steered me to Zetia, way before the TV comm'ls started. I had to bend my doc's arm to make her take me off statins. She was thinking that Lipitor was the new miracle drug. (Big Pharm propaganda and low cholest results rom some of her other patients) She was dubious that Zetia would be successful in my case. I proved her wrong, and have been taking it for over 3 yrs now.