Jeans are the worst, especially if there is a lot of sitting involved. Although I am old enough to know better I am young enough to be vain and want to wear fashionable "skinny" jeans. The adjective applies to the jeans and certainly not to me, but even in a super soft denim advertised as comfortable I am dying by the time I get a chance to change. I have a couple pair I can tolerate when it really matters to me, otherwise I live in three identical pair of grey Eddie Bauer cotton knit pants. They are soft, don't cling or bag, come in tall, and don't collect dog hair. (We have a German Shepherd who thinks she is a lap dog and a pug.) The pants are hideous and only come in dark grey. If I am going outside for more than a few minutes I wear long underwear and fleece lined pants.

There are several threads on here about clothing for sensitive skin. For me it is my left thigh that reacts to anything touching it. Skirts are better, especially on long car rides if I want to look presentable.