I'm posting this in hopes that somebody else has experienced this, and to help others who are going through this. I started taking Prempro (age 48) in 2011 for sever menopause symptoms i.e. Hotflashes, chills, etc., and it did a great job. At the beginning of 2014 I started having tremors in my chest, sleeplessness, mouth sores, anxiety, weepiness, pain in my feet/hands, headaches, sever dry mouth/ears and weight loss. My OBGYN ordered extensive tests, all results were normal and thought that I perhaps needed a higher dose but that didn't help & some symptoms became worse. Now it's Dec 2014 and my symptoms are Just unbearable, so I've decided to titrate down off of the Prempro and pray to God my menopausal symptoms are gone or at least less sever. In doing so I'm hoping the tremors, sleeplessness, mouth sores, etc. will go away, and perhaps it's just that I don't need the Prempro anymore! Has anybody had this before?