I've been on LDN since the beginning of October. I've had at least one relapse since, and I'm doing worse than ever right now. I'm also on Betaseron but have only been for a month. I haven't really been on anything long enough to help you with your decision! I will stay on LDN with hopes that it might help me, but so far it seems like nothing more than a placebo unfortunately. I hope it's doing some good.