Methylcobalamin is the active form biologically. Cyano is synthetic and has to go thru 4 chemical steps to become methyl in the body.
If you are part of the 10-30% of people who lack the gene to methylate you will be low biologically inspite of taking the cyano.
Since methyl is so inexpensive, and most people do not get DNA testing, it is best to today just skip cyano.
The way B12 is moved into the CSF (spinal fluid) is basically an osmotic gradient. To get it into the brain therefore the higher the serum level, the better the passage.
1000mcg (1mg) of B12 yields only 13 mcg absorbed into the body thru the small intestine. The rest leaves in the stool. So the dose looks high but it is only in reality 3-4 x the RDA for B12 because of this dynamic.
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
************************************
.
Weezie looking at petunias 8.25.2017
****************************
These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.