Hello rnicholson, no wise thoughts here, just the basics as I understand them. Symptoms vary greatly,healing or worsening. Think positively. Eat nutrient dense foods. Study for Mitochondrial health. Exercise to tolerance. Know your B-12 #(important for all but especially if Metfornin has been taken for extended time). If you feel pain may drive you to depression, seek help. If you cannot sleep, seek help. As this was your first post I am assuming that you are asking about healing pain already. I hope that is the actual scenario but do understand that the human body actually blocks speedy nerve regeneration. Some of the latest research involes knocking down these barriers. P-10 Knockdown. Post and tell us if there was an underlying factor. Usually that has to be addressed first. I would not be suprised if you could be going uphill in one area while going downhill in another. I had been in water therapy for two months working on my right leg when my left leg got lonely and joined the party. So give more info and these folks here have been there. They are a great bunch and have helped me greatly. Good Luck, Ken in Texas.