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Magnate
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Join Date: May 2007
Posts: 2,049
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Magnate
Join Date: May 2007
Posts: 2,049
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Autoimmune conditions span the gamut. AAG IS the underlying disease.
It took me a long time to get that thru my head.
AAG is a stand alone autoimmune disease.
The elevated ANA is caused by a yet unidentified antibody, hence a negative ENA.
Dry eyes and dry mouth are the product of a malfunctioning nerve to those organs and it will show up as lymphocytic infiltrate in a labial biopsy....because the nerves are undergoing the same inflammation as is present in connective tissue disease.
I have read that AAG is the sensory version of ALS (which is motor.) ALS affects the anterior horn, AAG the dorsal root. One is motor, one is sensory. Totally different diseases, but similar in that they are a degeneration of the nerve roots at the spine. ALS isn't secondary to any other disease, it just is. Same with AAG. It just is.
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