Hi, and thanks for all the great info.

The only reason I thought it might be the IVIG that made his psoriasis WORSE was that it got worse soon after he went off, not that it happened now. For the past 5 years or so this guy has been battling psoriasis in a major way.

Something had to trigger this to make it worse. We have had much stress in our lives due to our son's constant threats of suicide every single night. This started YEARS AGO and it was a nightly ritual of phone calls from social workers, from our son, from the police in California. And I noticed that Alan's psoriasis was getting worse and worse.

Perhaps the stress of all that was going on, maybe THAT triggered this Card 14 gene and not the IVIG (which I really did think did it).

I know stress is a tremendous trigger of these cases.

He's afraid to try any of the biologics because of what Celebrex did to him. He took it for 5 days and it landed him in the isolation unit of the hospital. He was covered in a deep rash ALL over his body. His face swelled up like a balloon, and everyone was running around with hazmat suits and I kept saying "Listen he took Celebrex, he's probably allergic, give him some benedryl". No one listened. They called in these specialist and one guy said "Looks like Rocky Mountain Spotted Fever". I was going nuts. FINALLY, after countless blood tests and this and that, some lightbulb must have gone off because they gave him Benedryl and in a few days he was just fine. He was told "NEVER TAKE CELEBREX AGAIN.

And he hasn't. How odd that one med could have some an adverse reaction.

Thanks guys

Melody