This is very interesting information for me, as I have such a myraid of symptoms with a strong family history of autoimmune disease. I have a negative ANA but positive acetylcholine ganglionic receptor antibodies. My ANA was low positive 15 yrs ago, and with mildly dry eyes & mouth with sensory neuropathy just beginning, they thought maybe Sjogren's. I took Plaquenil for about 9 yrs and ANA was always negative after that. SSA/SSB always negative. I stopped taking Plaquenil about 3 yrs ago since my nerves kept getting worse but nothing showing in my bloodwork.

Is there a way to find a neurologist-rheumatologist-autonomic specialist without going to the Mayo or Hopkins?! My doctors have no clue & don't seem to care much. I like my neuro as a person, but when I showed him the Liza Jane spreadsheet and suggested we may be missing something, he just smiled & said I've had a thorough workup. I feel like I'm wasting time, money & sanity.

My 17 yo was just diagnosed with mild POTS via a tilt-table test, I know I have this without having to be tested.