Somehow my prescription for LDN was mixed up and I was without for three weeks........I do have it again now. However, most of the MS symptoms came back after being off it for a week or so, bladder was worse, pain, weakness, sensitive to temperature change, etc., etc., etc. Sometimes I've wondered if it was really doing anything and now I know. Besides holding this monster at bay for so many years, it really helps in my day-to-day living. I'm on it for life!