Lisa, I have generalized MG, not OMG, but I've taken prednisone on and off for 16 years. Mike's correct when he talks about quality of life. I've been on a dosage as high as 100mg. I've not had skin cancer, but I'm on the lookout for it. I have, however, had cataract surgery on both eyes, I have osteopenia, and osteoarthritis. As Cate mentioned, I've had high blood sugar, high cholesterol, insomnia and mood swings. It can also thin the skin and cause it to easily bruise.

To be clear, due to personal choice and the fact that my MG is considered mild to moderate, I chose prednisone, imuran and mestinon over other medications and treatments. Do I regret my decision, ask me in five more years.
Jim