I haven't tried dermatran specifically because my insurance didn't cover that pharmacy, but I did get a similar compound cream from my local specialty pharmacy. I have a lot of pain in the ball of my foot (at first) and it helped a lot, but I mostly only use it on the bad days now, since there's nothing else I can take. I suggest having your doctor wrote a script for the cream you can take to your local specialty pharmacy and work with them. I had problems with the medication in the cream not dissolving (there were little chunks) and they made me a new one without me having to bring in the bad one. I live in a city and normally there's no customer service. A local place can work with you better than a national place. Just a thought. But there is no miracle cream. I can tell you that in the beginning, it was a life saver for me. Now, it helps on the bad days and thus is worth it for me.