I too experienced this over time with PN. My massage therapist and PT noticed it and they do not know each other. I am now about 20 pounds lighter than I was four or five years ago and I was already thin, no changes to diet or efforts to lose weight.

Muscle wasting can absolutely occur with all over body PN. My doctors advised that I keep up the workouts (sometimes easier said then done) but other than that, nothing can be done about the wasting.