WannaGet, I haven't noticed any effect, and I have been taking it regularly. Of course, nerve regeneration is a long term thing, and it is fairly inexpensive, so I am keeping it in my list 'o stuff I take. I am also on Day 5 of Tramadol cessation and that is really messing with me , as noted above. I don't recall it having this much effect before, maybe I took it a bit longer this time. BE CAREFUL with this stuff if you ever take it.