Background; Before Rytary I was able to walk, exercise 1/2 hr daily,and function adequately 75% of the time. I took 12 25-100 Sinemet daily. My downtime between dosages of Sinemet averaged 15 minutes. I have been on RYTARY ER 48.75-195 MG Caps 3 every 8 hrs. 9PM 5AM 1PM. It has only been 4 days. My 9PM caps have extended my sleep to approx 8 hrs and I feel good when I awake to take my 5AM dose. Before Rytary I would get up after 5 hrs of sleep for 2 and !/2 hours shuffling around for 15 minutes before my Sinemet started to kick in. I would then go back to bed for 2 hours. Although my 9 PM Rytary last 8 hrs my 2 other doses seem only to last 6 to 7 hours so I supplement my down time with 1 Sinemet. I postulate that I only get 6 to 7 hours with my daytime pills because of food interfering with absorption ie. any kind of food. I also think stress plays a part. When I am on I feel much better than the Sinemet, (think more clearly, function better} and don't have to remember to take pills every 2 hrs. I have experienced nausea. The co-pay for me is $40 monthly. I realize it has only been 4 days but it is a new drug and wanted to get info out. I will update you again in a couple weeks.