Hi there,

Thank you for the replies,

maybe I haven't explained this properly so ill read the letter from proff

"We proceeded to skin biopsy of the calf which showed a clear increase of intra-epidermal fibers with the gold standard structural marker pgp9.5 at 11 fibers/mm the normal range being 6.5. Other intra-epidermal markers were similary increased, including GAP43 which is a marker for regenerating fibers 3.1 fibres. the normal range being 1fibre/mm. This is in contrast to conditions such as diabetic neuropathy where there is a loss of intra-epidermal nerve fibers.

The skin biopsy findings are in keeping with neuroinflammation or autoimmune conditions and can be seen in patients who have had drug treatments or chemotherapy" He goes on to suggest this is seen in sjogens syndrome and said voltage gated potassium channels can also cause this.

does this make more sense as it makes none to me! trust me to be different.!!?