Quote:
Originally Posted by Mark in Idaho
You may not think you have any caffeine sensitivity but you may be causing brain fatigue. Caffeine is an excito-toxin. It stimulates the brain cells to fatigue or even death. You should limit your caffeine to one serving per day or less.
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Caffeine is an adenosine receptor antagonist - it prevents adenosine from slowing down neurons. Why is it excito-toxic to the brain?
I was under the impression that excito-toxins are neurotransmitters like Glutamate, which can allow a massive influx of Calcium Ions to the nerve cell and therefore excite them to death. Does Caffeine do anything similar to that in high doses?
And yes, Glutamate is a neurotransmitter and an excito-toxin. Any substance that enhances its release is toxic to the brain. Does Caffeine affect Glutamate release?