It appears that the advantage of Sottopelle is a steady infusion of hormone (testosterone in men) and some convenience as yoiu don't have to take constant daily doses by patch, gel, injection, etc. On the other hand, an expensive trip to the doctor every 3 to 6 months for a new pellet is a drawback.

Testosterone appears to be important. See, for example, http://www.medicalnewstoday.com/articles/264067.php. The question is, is Sottopelle's anecdotally impressive result due to just testosterone or is it the delivery method and pharmacokinetics that is the benefit? Would rhe patches, etc. do the same thing?