As I said, I only take it before sleep. It has an 5-7 hour half life which means it is active for a short period compared to many meds. If the 300 mgs 3 x a day does not work, a higher dose before bed may work better. If I forget my dose and take it later, I will not notice a benefit for 1 to 1 1/2 hours. Then, it kicks in good and my body/muscle tension releases so I can relax to sleep.