Yes, I believe that it very well could be. My husband started having the RLS while he was on Paxil. (He was on a Paxil/Buspar regimen for years.) When he changed psychiatrists, the new doc changed his meds to the Effexor (375mgs .. I think this is high), Ambien, Mirapex and Provigil. My husband takes the Effexor for anxiety and depression. He has been on theaw new prescriptions for apprximately three years.

I have read that some anti-depressants do cause the RLS. I guess another thing I should ask his doc about? I am wondering if they (husband and doc) might think that the RLS would be an okay trade off, as long as his anxiety and depression are under control?