This is my 40th day on Rytary (3-47.85/195MG capsules 4 times/day, every 4 hrs starting at 6AM) and I have recently had some moderate wearing off in afternoons around 4-5PM that lasts until my 6PM dose kicks in (I take 3 capsules at 2PM and my last 3 of the day at 6PM). Tomorrow I'm going to try an alternate dosing schedule my MDS gave me were I take 3 capsules every 3 hrs starting at 6AM then 9AM, Noon and 3PM with a single capsules at 6PM. We'll see how it goes. I have found that for me Rytary is very sensitive to when I eat (especially if my meal is high protein) My MDS recommended I wait 1 hr after taking Rytary for meals and it appears he was correct.

Slumpy