Getting the right dosage is important for all drugs. However, my experience so far is that for Rytary it is crucial. It also is very tricky to achieve. I wondered why Impax came out with so many variations of Rytary. Now I understand.

I started out taking 3 caps of 48.75MG-195MG 3 times a day (at 6am-12pm-6pm). This led to daytime dyskinesia, wearing-off and sleepless nights. After trying additional modifications, I'm currently taking 2 caps of 48.75-195MG combined with one cap of 36.25-145MG at 6am and 10:30am followed by one cap of 48.75MG-195MG combined with two caps of 36.25-145MG at 5pm and bedtime.

I'm also taking 100mg of Amantadine twice a day.

This combination seems to be working, but I'm guessing that it will be a continuing process to get the dosage right as symptoms change.

Rytary is a great drug, although getting my insurance company to agree to pay for it with a reasonable co-pay is a battle.