There are actually studies that show that Lyme bacteria can change into a round form, and possibly invade cells of its host to evade antibiotics. Some of these tests have been done in cultured human cells of various types only, so it is yet unclear as to whether or not the same holds true for human hosts, but it does raise questions...so whether or not the spirochete involved in Lyme infection changes forms still is a possibility.

Plaquenil has been shown to have an effect on killing this round/cystic form of the bacteria.