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Old 04-21-2015, 08:48 AM
glenntaj glenntaj is offline
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glenntaj glenntaj is offline
Magnate
 
Join Date: Aug 2006
Location: Queens, NY
Posts: 2,857
15 yr Member
Default It can be difficult--

--to distinguish symptoms of neuropathy from those of vascular insufficiency--especially since, technically, neuropathy can be caused by certain types of vascular insufficiency, either through the compressive effects from swelling putting pressure on nerves when blood flow is not normal and "pools", or through nerves being starved for nutrients and oxygen (and troubled in their removal of metabolic wastes) by lack of proper circulation. Diabetic neuropathy, for example, is though to be primarily an ischmeic/circulatory result; while high sugar levels can damage nerves directly they have a more widespread effect on capillaries, causing dysregulation of nitric oxide pathways and compromising blood flow to nerves. (And, of course, diabetes also leads to all sorts of things that start from compromised circulation--blindness, poor wound healing, coronary artery disease, kidney problems.)

I would think that if one's symptoms were PRIMARILY from peripheral artery disease, there would be more waxing and waning of symptoms, dependent on position and degree of exertion, whereas neuropathy symptoms would not be as dependent on these and be more constant.
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