Quote:
Originally Posted by johnt
This is something you can try yourself, albeit not entirely safely.
Back in 2012 moondaughter started a thread on "DIY easy high dose anti-oxidant therapy"
http://neurotalk.psychcentral.com/sh...light=liposome
Her post pointed to a video showing how you could make liposomes (basically nano sized globules of fat surrounding an active ingredient) of Vitamin C.
I carried out an experiment (Post 6 in the thread) to determine whether this process could work for dopamine (which ordinarily cannot cross the BBB). I detected a small improvement in my tap-test results. Unfortunately, I didn't have a source of pure dopamine, and had to rely on extracting the dopamine from banana skin. With so many uncertainties the outcome was unclear.
If anyone knows how to get pure dopamine, I'd be interested to know. This would allow me to repeat the experiment in a more controlled manner. I'd also appreciate any advice on how to measure the size of the liposomes produced. Does anyone have an electron microscope in their garage? (Not such a far fetched fantasy: the great advances made in technology mean that all types of previously state of the art equipment become cheap.)
Other possible candidates for the liposomal route include levodopa and apomorphine.
John |
BTW, here's a link to the full study ..
http://pubs.acs.org/doi/pdf/10.1021/nn506408v
It's staggering to see the number of researchers involved and the depth they released. Apparently the nanoballs used have been used to pass other chemicals into the brain before and they seem to totally dissolve and release dopamine gradually.
Best of all if this delivery system is already in use this could get released to phase 1 trials quickly.
The really nice part is that study was open source published and financed by the Indian government, not a drug company. It's bound to actually work then. IMO, this study has legs. We all may have to "vacation" in India someday to get on this protocol.
From the study ..
Conflict of Interest: The authors declare no competing
financial interest.
Acknowledgment. We are grateful to the Director of CSIRIITR,
Lucknow, India, for his continuous support in the present
work. K.C.G. thanks ICMR, New Delhi, India, for awarding a
Distinguished Scientist Chair. This work was supported by the
Department of Science and Technology as Woman Scientist and
Ramanna Fellow Grant to K.S. and CSIR network project
BSC0108 (MedChem) to R.K.C. Technical help of Mr. Punit Khare
flow cytometry analysis and Mr. Jai Shankar and Ms. Nidhi
Arjaria in TEM analysis is acknowledged. This is manuscript
communication number 3284.
Supporting Information Available: Nine supplementary figures.
This material is available free of charge via the Internet at
http://pubs.acs.org.