Thank you so much for the above information on B12. I really appreciate your informed discussion I had no idea I should be taking my methyl B12 away from food for instance. I will do so from now on. Now wonder it never has seemed to make a difference whether I took it or not. I agree the methyl form is best--and why not take it rather than not? Meanwhile I have a problem taking methyl folate or at least so I think. Maybe if I take it by itself rather than in a methyl B pill it will be OK. Wiped me out for two days the two times I took it. Pretty scary! I could hardly move I felt so under it. My grandmother used to get B 12 shots and swore by them. My condition seems to be more complicated. I had 23 and me done and discovered yes I do have inherited B12 tendency towards deficiency as well as multiple methyl and immune system difficulties--including a tendency to have low blood pressure with runaway inflammation from stress from ACE and other mutations which often leads to migraines etc. etc. But that is another topic, eh? Or is it? Things could get a bit confused here. I am new to the forum so will need to find my way...