I am a member of the Singum Biosciences Team and wanted to share more information on our proprietary coffee extract, EHT®. EHT® (chemical name: Eicosanoyl-5-hydroxytryptamide) is a molecule found in coffee, unrelated to caffeine. Numerous epidemiological studies have shown a strong inverse correlation between coffee consumption and AD and PD as well as other chronic diseases of aging, most notably, diabetes. No such epidemiological evidence exists for similar efficacies of other caffeinated drinks such as tea or soda. Therefore the beneficial effects of coffee for neurodegenerative disease cannot be exclusively attributed to caffeine. In fact coffee contains over 1,000 different compounds and the evidence for caffeine’s benefits are, for the most part, indirect. Moreover, in several studies decaffeinated coffee has been shown to provide beneficial effects, albeit not to the extent associated with whole coffee.
The following studies listed which can be found on Pubmed demonstrate how EHT provides cognitive support
1. Therapeutic benefits of a component of coffee in a rat model of Alzheimer’s disease. Basurto-Islas G, Blanchard J, Tung YC, Fernandez JR, Voronkov M, Stock M, Zhang S, Stock JB, Iqbal, K. Neurobiol Aging. 2014. (Epub ahead of print). PMID: 25034344
2. Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson’s Disease. Lee KW, Im JY, Woo JM, Grosso H, Kim YS, Cristovao AC, Sonsalla PK, Schuster DS, Jalbut MM, Fernandez JR, Voronkov M, Junn E, Braithwaite SP, Stock JB, Mouradian MM. Neurotherapeutics. 2013. 10(1):143-53. PMID: 23296837
3. Enhanced phosphatase activity attenuates a-synucleinopathy in a mouse model. Lee KW, Chen W, Junn E, Im JY, Grosso H, Sonsalla PK, Feng X, Ray N, Fernandez JR, Chao Y, Masliah E, Voronkov M, Braithwaite SP, Stock JB, Mouradian MM. J Neurosci. 2011. 11:31(19):6963-71. PMID: 21562258

Also included here I a recent paper reviewing the Evidence Surrounding the Relation between Coffee and Cognitive Function
1. jacobspublishers.com/index.php/j-j-food-nutri-1-1-002

In regards to your observation on Signum Biosciences having an association with The Michael J Fox Foundation you are correct. We have received grants from the foundation to conduct research on EHT.

We are more than happy to answer any other questions that you may have on EHT.