The damage from fluoroquinolones is insidious...and it may add onto other damage from other environmental triggers that affect DNA of mitochondria. There are over 100 causes of neuropathy.
And some people may have additive situations of damage... some of this, and some of that...etc.

I haven't seen exact time frames given, yet. But each person is different. It seems to me that PN tends to be concealed for a while, until a certain plateau is reached and then symptoms become noticeable. There is evidence in the CMT community that Levaquin can trigger an asymptomatic (no symptoms yet) CMT adult into a deterioration. Given the highly variable presentations of CMT in those patients who inherit it, one has to
consider environmental triggers that may be in play for all these various individuals.

http://aop.sagepub.com/content/45/10/1312.extract

http://link.springer.com/article/10....01213830-00089

http://www.hnf-cure.org/neurotoxic-d...tooth-disease/

PN is very complicated, and involves so many factors, that no one clear answer appears to be accessible about it. Some of the posters who come here have immediate reactions to fluoroquinolones, and others have delayed reactions.