Here are some studies, which lend validity to pre-diabetes as
an instigator of PN....Keep in mind that not all diabetics get PN, or some of the terrible cardiac or vision deteriorations.
2008:
Quote:
Neurologist. 2008 Jan;14(1):23-9. doi: 10.1097/NRL.0b013e31815a3956.
Impaired glucose tolerance and neuropathy.
Smith AG1, Singleton JR.
Author information
Abstract
BACKGROUND:
Peripheral neuropathy is common. Diabetes is the most common cause, accounting for approximately half of cases, but up to 1/3rd of neuropathy patients have no identifiable etiology. Among this population, impaired glucose tolerance (IGT or "prediabetes") is observed in approximately 40%. The exact nature of the relationship between IGT and neuropathy is debated.
REVIEW SUMMARY:
A variety of evidence suggests IGT causes neuropathy. Neuropathy may occur early in diabetes. The neuropathy associated with IGT is clinically similar to early diabetic neuropathy, with preferential injury to small nerve fibers resulting in pain and autonomic dysfunction. IGT and diabetic neuropathy patients share abnormal microvascular endothelial dysfunction. Treatment of IGT subjects with diet and exercise reduces risk of progression to diabetes, and those with neuropathy experience a short-term improvement in small fiber function with sustained benefit for pain. An evolving literature links other aspects of the metabolic syndrome to peripheral neuropathy.
CONCLUSIONS:
IGT is common in peripheral neuropathy patients. The extent to which IGT directly causes nerve injury as opposed to being a covariant with other equally or more important features (eg, obesity, metabolic syndrome) remains to be determined. Preliminary data suggest diet and exercise counseling may be a useful treatment strategy.
PMID:
18195653
[PubMed - indexed for MEDLINE]
|
from
http://www.ncbi.nlm.nih.gov/pubmed/18195653
2010:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797976/
Quote:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797976/
.....In conclusion, neuropathic changes predominantly affecting small fibers appear to occur more commonly in those with IGT than in the normal population, and ongoing prospective studies should provide confirmation of these initial observations. If confirmed, an internationally agreed definition as to what constitutes IGT neuropathy is required, and the noninvasive techniques of corneal confocal microscopy and LDIflare may be useful in assessing longitudinal cohorts and potential pharmacological interventions for what is often a painful condition.
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2012:
http://onlinelibrary.wiley.com/doi/1...12.00390.x/pdf
And the debate continues. I'd like to know how many of these patients are on statins when they are evaluated? hmmmm?
How many had Cipro, or Levaquin recently?
The studies always go round and round. But controlling sugar and high glycemic carbs in the diet seem to help many people who come here looking for information. Cutting back is not a drug, doesn't cost BIG PHARMA bucks, and provides a potential
way to reduce pain and discomfort and not suffer the side effects of Lyrica or other drugs.
It is certainly worth trying IMO. By the time the answers are more forthcoming on this subject, they will have changed all the parameters being used now, for pre-diabetes. I personally think that medicine is overly aggressive with this. But that is my opinion. I think anyone coming here should clean up their diet, and if they feel better, then that is the answer for THEM. Everyone is different after all.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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