Palmitoylethanolamide sold as PeaPure is a complex fatty acid discovered by an Italian Nobel Prize winner. It apparently modulates mast cell production and communication within the microglia. It is used in Europe for neuropathic pain. I order it from the Netherlands, payment is in euro online but exchange is good. I have been taking it a while. Can't say for sure how much it has helped but I'm doing fairly well, no side effects, so I am not about to stop taking it!