The severity of multiple Sclerosis is also dependant on the permeabilty of the BBB. See http://www.medicalnewstoday.com/medi...p?newsid=67397
Jefferson Immunology Researchers Show Blood-brain Barrier Damage Could Affect MS Severity
Main Category: Multiple Sclerosis News
Article Date: 11 Apr 2007 - 14:00 PDT
Immunology researchers at the Kimmel Cancer Center at Jefferson studying a multiple sclerosis (MS)-like disease in mice have shown that the amount of "damage" to the central nervous system's protective blood-brain barrier - in essence, opening it - almost always correlates to the severity of the disease. The findings, reported online in the Proceedings of the National Academy of Sciences, can be used for testing potential MS therapies and for better understanding the role of the blood-brain barrier in disease processes

I wonder how this fits in, is there a deficiency of something that causes MS??
Ron