whenever I've had prednisone for any reason, it makes me hungry. Might make me a little grumpy. Gives me some energy. Sometimes I've gotten fatigue, but that might have been related to the particular flare I had at the time.

I've taken it in high doses by IV for vision related stuff, and taken it as a short course of oral prednisone for non-vision related stuff. (the Optic Neuritis Treatment Trial recommends that you do IV steroids for vision related flares)

I've also had a couple of extremely low dose oral prednisone for pain relief when I had frozen shoulder about a year and a half ago. (frozen shoulder was NOT ms related. Probably got that from a nurse giving me a flu shot in the wrong spot on my arm). Even the extremely low dose prednisone made me hungry. But it was awesome for the pain from the frozen shoulder. Was the only thing that controlled the shoulder pain. Morphine didn't even touch the shoulder pain, but the prednisone was awesome.